BioMed Research International / 2013 / Article / Fig 3

Research Article

Defects in Base Excision Repair Sensitize Cells to Manganese in S. cerevisiae

Figure 3

Attenuation of the cytotoxic effect of Mn2+ by exogenous antioxidants. Sensitive strain ubc13 was treated with 1.5 mM Mn2+, 1.5 mM Mn2+ plus 10 mM glutathione (GSH), and 1.5 mM Mn2+ plus 20 mM N-acetylcysteine (NAC), as described in Section 2. Survival was determined relative to untreated strain (100% survival). Wild-type strain was treated with 2 mM Mn2+, with or without cotreatment with GSH and NAC, as described in Section 2. At least 5 independent colonies were tested. Average survival plus standard deviation is shown.

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