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BioMed Research International
Volume 2013, Article ID 295890, 5 pages
Clinical Study

The Effect of Silver Nitrate Pleurodesis after a Failed Thoracoscopic Talc Poudrage

1Division of Thoracic Surgery, “G. Mazzini” Hospital of Teramo, Faculty of Medicine and Surgery, University of L'Aquila, Piazza Italia 1, 64100 Teramo, Italy
2Division of Thoracic Surgery, Sant'Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “Sapienza”, Via di Grottarossa 1035, 00189 Rome, Italy
3Fondazione Eleonora Lorillard Spencer Cenci, Via Di Casal de' Pazzi 10, 00156 Rome, Italy

Received 1 May 2013; Accepted 29 July 2013

Academic Editor: Surinder K. Jindal

Copyright © 2013 Cecilia Menna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Chemical pleurodesis is the procedure of choice in the management of recurrent malignant pleural effusions (MPE). Talc is probably the most effective sclerosant, with a success rate of 80%. The aim of this study is to demonstrate the effectiveness of silver nitrate solution (SNS) pleurodesis after an unsuccessful thoracoscopic talc poudrage. Methods. Between 2011 and 2013 one hundred and nine patients with unilateral MPE underwent thoracoscopic talc poudrage. Seventeen patients who did not obtain a successful pleurodesis via thoracoscopic procedure were considered for an SNS slurry. The pleural injectate consisted of 100 mL 1% SNS with 10 mL of lidocaine (100 mg/5 mL). The SNS procedure was undertaken once and repeated with the same dose in 5 patients. Results. The duration of follow-up period was 30 days. Subjective pain was low and the same before and after SNS procedure ( value = NS). The mean daily fluid drainage was statistically different ( ) comparing values before (  mL) and after SNS procedure (  mL). After 30 days from SNS procedure recurrence of pleural effusion was observed in 2 patients (11%). Conclusions. The present study demonstrates that SNS is an effective agent for producing pleurodesis after a failed thoracoscopic talc poudrage.