Review Article

[Retracted] Genetic and Functional Profiling of Crohn's Disease: Autophagy Mechanism and Susceptibility to Infectious Diseases

Figure 2

More than 90 distinct genomic susceptibility loci have been found to be associated with an increased risk of developing CD. The genes variants relate largely to the innate immunity genes, in particular to the disruption of the innate and adaptative arms of the immune systems, to the process of autophagy, to the epithelial barrier function, and to the activation of the endoplasmic reticulum stress response.
297501.fig.002