Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba

Table 2

Relative organ weight (g/1000 g of body weight) and body weight (g) of male rats receiving PPE for 6 months.

Organs	Dose of PPE administered (mg/kg/day)
	Control	Tragacanth	11	110	550	1100
	𝑛=15	𝑛=15	𝑛=15	𝑛=14^a	𝑛=15	𝑛=15
Brain	3.88±0.39	3.72±0.33	3.78±0.22	3.91±0.31	4.21±0.26^#	4.55±0.28^∗,#
Heart	2.63±0.28	2.74±0.12	2.68±0.28	2.89±0.13^#	3.40±0.25^∗,#	3.31±0.27^∗,#
Lung	3.07±0.31	3.18±0.19	3.45±1.04	3.31±0.19	3.70±0.29^∗,#	4.02±0.43^∗,#
Liver	23.86±2.02	24.38±1.82	25.57±1.68	33.65±3.62^∗,#	49.65±2.37^∗,#	59.81±3.17^∗,#
Stomach	4.01±0.40	3.81±0.50	4.06±0.39	4.53±0.47^#	5.20±0.43^∗,#	5.64±0.39^∗,#
Spleen	1.68±0.20	1.55±0.16	1.60±0.15	1.77±0.18^#	2.14±0.29^∗,#	2.18±0.14^∗,#
Right kidney	2.33±0.17	2.27±0.21	2.38±0.21	2.71±0.18^∗,#	3.12±0.25^∗,#	3.43±0.31^∗,#
Left kidney	2.21±0.19	2.20±0.22	2.22±0.22	2.63±0.20^∗,#	3.04±0.22^∗,#	3.35±0.24^∗,#
Right testis	5.52±0.53	5.16±0.70	5.40±0.43	5.48±0.52	6.25±0.55^∗,#	6.61±0.49^∗,#
Left testis	5.60±0.64	5.24±0.82	5.41±0.44	5.50±0.56	6.27±0.58^#	6.62±0.46^∗,#
Right adrenal	0.071±0.01	0.071±0.02	0.067±0.01	0.080±0.01	0.088±0.01^∗,#	0.080±0.01
Left adrenal	0.075±0.01	0.082±0.01	0.077±0.02	0.087±0.02	0.095±0.01^∗	0.092±0.02^∗
Bladder	0.328±0.06	0.327±0.06	0.313±0.06	0.365±0.09	0.418±0.04^∗,#	0.368±0.12
Initial body weight	113.89±4.57	113.25±4.70	114.19±5.91	114.46±8.98	113.15±4.70	113.50±6.34
Final body weight	533.07±55.27	573.47±52.91	569.32±42.54	545.16±49.74	506.27±30.97^#	461.69±29.35^∗,#

The values are expressed as the mean ± SD.
∗Significantly different from water (𝑃<0.05).
#Significantly different from 0.5% tragacanth (𝑃<0.05).
aDied from feeding extract into respiratory tract.