Acute and Chronic Oral Toxicity of a Partially Purified Plaunotol Extract from Croton stellatopilosus Ohba

Table 5

Hematological values for female rats receiving PPE for 6 months.

Parameters	Dose of PPE administered (mg/kg/day)
	Water	0.5% tragacanth	11	110	550	1100
	𝑛=15	𝑛=15	𝑛=15	𝑛=14^a	𝑛=15	𝑛=15
Hematocrit (%)	30.86±0.82	30.85±1.40	30.88±0.92	30.82±1.28	31.86±1.51	31.62±1.44
RBC; (×10^6 cells/mm^3)	8.93±0.37	8.97±0.52	8.98±0.34	8.80±0.38	9.29±0.60	9.65±0.37^∗,#
Hemoglobin (g/dL)	16.60±0.42	16.72±0.60	16.79±0.53	16.73±0.64	17.00±0.72	16.73±0.74
MCV; (µm^3/red cell)	53.77±0.50	54.23±0.72	54.40±0.59	54.27±0.52	53.37±0.96	52.90±0.55^∗,#
MCH; (pg/red cell)	18.61±0.47	18.69±0.58	18.71±0.49	19.00±0.47	18.34±0.89	17.34±0.53^∗,#
MCHC; (g/dL RBC)	34.60±0.85	34.45±0.83	34.38±0.74	35.05±0.74	34.33±1.32	32.78±0.93^∗,#
WBC; (×10^3 cells/mm^3)	1.95±0.50	2.05±0.61	2.40±0.55	2.49±0.78	2.56±0.69	2.82±1.04^∗
Neutrophil (%)	22.36±4.49	25.03±9.50	24.65±8.51	19.86±4.82	21.35±11.41	20.94±3.38
Eosinophil (%)	1.64±0.56	1.50±0.79	1.27±0.70	1.20±0.47	0.73±0.34^∗,#	0.74±0.55^∗
Lymphocyte (%)	72.25±5.08	71.95±9.23	72.53±8.55	76.97±4.91	75.19±12.68	75.80±3.49
Monocyte (%)	1.94±2.89	0.89±0.30	0.93±0.36	1.05±0.65	1.43±1.63	0.93±0.67
Basophil (%)	0.83±1.02	0.62±0.41	0.63±0.40	0.92±0.46	1.29±0.62^#	1.59±0.61^#
Platelet; (×10^3 cells/mm^3)	1,068.73±121.33	1,039.23±102.92	1,012.80±71.82	1,015.57±97.02	1,240.60±106.72^∗,#	1,334.80±101.78^∗,#

The values are expressed as the mean ± SD.
∗Significantly different from water (𝑃<0.05).
#Significantly different from 0.5% tragacanth (𝑃<0.05).
aDied from feeding extract into respiratory tract.