Nano Polymeric Carrier Fabrication Technologies for Advanced Antitumor Therapy
Figure 4
TEM images show the well-defined structure of functional nanocarriers engineered by tuning the monomer ratio, tailoring the polymer composition, and regulated by different particle’s formation mechanisms. (a) The flory interaction parameter (), where and are the solubility parameter of the polymer and solvent, respectively, is the molar volume of solvent, is Boltzemann constant, and the value of 0.34 is entropic contribution; (b) the hydrophilic to lipophilic balance (HLB), where HLBgroup is the constant of different groups along polymer chain; (c) the particle number calculation in emulsion (), where is consistent in the range of 0.37–0.53, , , , and are the rate of total radicals produced, the rate of the particle volume increase, the surface area of a surfactant, and total number of surfactant, respectively; and (d) the electrostatic repulsion energy (), where the , and are the electronic constant of the solvent, Boltzmann’s constant, the number of ion, the capacity of solvent, the double layer potential of the diffusion layer, the thickness of the double layer, and the distance between two particles, respectively.
