In Vitro and In Vivo Antimalarial Evaluations of Myrtle Extract, a Plant Traditionally Used for Treatment of Parasitic Disorders

Table 1

In vitro and in vivo antiplasmodial activity and cytotoxic effect on mammalian cell lines.

Sample	In vitro antiplasmodial activity of Plasmodium falciparum  IC50 (μg/mL)		Cytotoxicity IC50 (μg/mL)				In vivo antiplasmodial activity of Plasmodium berghei % inhibition
	K1	3D7	MCF7	HepG2	WEHI	MDBK
Myrtus communis L.	35.44	0.87	>100	>100	>100	>100	84.8±1.1 (day 5); 63.1±4.1 (day 15)
Chloroquine	0.02	0.01	23.90	34.60	12.29	>100	100
Artemisinin	0.001	0.004	>100	>100	>100	>100	N.D
Tamoxifen	N.D.	N.D	3.60	4.38	19.1	6.35	N.D

N.D.: not done.