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BioMed Research International
Volume 2013, Article ID 316430, 6 pages
Clinical Study

Factors Affecting Bilirubin Levels during First 48 Hours of Life in Healthy Infants

1Division of Neonatology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey
2Department of Anesthesiology and Reanimation, Ege University Faculty of Medicine, Izmir, Turkey

Received 19 April 2013; Revised 18 May 2013; Accepted 20 May 2013

Academic Editor: Sohinee Bhattacharya

Copyright © 2013 Betul Siyah Bilgin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the relationship of delivery type, maternal anesthesia, feeding modalities, and first feeding and meconium passage times with early bilirubin levels of healthy infants. Methods. Cord, 24 hours’ and 48 hours’ total bilirubin levels were measured in 388 study infants. Results. Infants born with cesarean section were fed later and more often had mixed feeding. First meconium passage was delayed with general anesthesia. Cord, 24 and 48 hours’ bilirubin levels were not correlated with first feeding time, meconium passage time, mode of delivery, existence and type of anesthesia, and feeding modalities. Being in high intermediate risk zone at 72 hours of Bhutani’s nomogram was only related to first feeding time and high cord bilirubin level. Late preterm infants were more frequently born with cesarean section and offered supplementary formula. Therefore, first meconium passage times and bilirubin levels were similar in the late preterm and term infants. Conclusions. Type of delivery or anesthesia, late prematurity, feeding modalities, and first meconium passage time were not related to early bilirubin levels in healthy neonates, but delayed first feeding and high cord bilirubin levels were related to be in higher risk zone for later hyperbilirubinemia.