Gsk-3<i>β</i> Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

<table>Scheme of the experimental protocols. NIC: nonischemic control; IC: ischemic control; PRE: ischemic preconditioning; POS: ischemic postconditioning; LiClpre and LiClpos: LiCl administered previously to ischemia or early during reperfusion, respectively; <svg height="11.3625" id="M6" style="vertical-align:-0.15013pt" version="1.1" viewbox="0 0 63.862499 11.3625" width="63.862499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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</svg>: ischemic preconditioning in presence of wortmannin; <svg height="11.6875" id="M7" style="vertical-align:-0.20473pt" version="1.1" viewbox="0 0 64.487503 11.6875" width="64.487503" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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t-108.5 38.5q-44 0 -56 -12q-11 -8 -11 -47z" id="x50"></path></g><g transform="matrix(.017,-0,0,-.017,9.633,11.363)"><path d="M381 665q131 0 226.5 -93t95.5 -239q0 -158 -96 -253t-238 -95q-137 0 -231 95t-94 238q0 142 92.5 244.5t244.5 102.5zM359 629q-89 0 -151 -74.5t-62 -208.5q0 -141 69 -233t175 -92q90 0 150.5 74t60.5 211q0 152 -69 237.5t-173 85.5z" id="x4F"></path></g><g transform="matrix(.017,-0,0,-.017,22.331,11.363)"><path d="M409 504l-29 -5q-16 60 -44.5 96t-86.5 36q-54 0 -82.5 -32t-28.5 -77q0 -51 30.5 -82.5t96.5 -65.5l35.5 -18t33 -19.5t33.5 -23.5l27 -25.5t24.5 -32t13.5 -36.5t6 -45q0 -80 -62 -134.5t-160 -54.5q-47 0 -98 15q-22 7 -50 21q-8 23 -27 155l30 7q7 -27 18 -52
t30 -51.5t49 -42.5t67 -16q56 0 88 32.5t32 87.5q0 51 -31.5 82t-98.5 67q-80 44 -110 73q-55 53 -55 124q0 75 56 126.5t150 51.5q53 0 126 -23z" id="x53"></path></g><g transform="matrix(.017,-0,0,-.017,34.162,11.363)"><path d="M535 230h-212v-233h-58v233h-213v50h213v210h58v-210h212v-50z" id="x2B"></path></g><g transform="matrix(.017,-0,0,-.017,47.914,11.363)"><path d="M956 650v-28q-52 -7 -69 -22.5t-39 -77.5q-60 -175 -165 -533h-31l-175 499h-2l-163 -499h-31l-164 535q-18 60 -36 76.5t-65 21.5v28h243v-28q-53 -7 -63 -18.5t3 -49.5l122 -412h2l162 499h29l175 -500h2q87 277 113 401q12 45 0.5 59t-68.5 21v28h220z" id="x57"></path></g>
</svg>: ischemic postconditioning in presence of wortmannin; IMIpre and IMIpos: IMI administered previously to ischemia or early during reperfusion, respectively.</table>

BioMed Research International

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Figure 1

Figure 1: Gsk-3<i>β</i> Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats 

BioMed Research International

Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

Figure 1