Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

Figure 5

Representative immunoprecipitated and summary data of P-GSK-3β/VDAC and GSK-3β/VDAC associations in cytosolic fraction from nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE+W (wortmannin), POS+W, lithium, and IMI treated hearts. These data show that the P-GSK-3β/VDAC association was minimal in IC hearts and maximal in hearts treated with GSK-3β inhibitors. W decreased significantly the P-GSK-3β/VDAC association detected in PRE and POS. *𝑃<0.05 versus NIC; ^#𝑃<0.05 versus IC; ^ξ𝑃<0.05 versus PRE and POS.