Gsk-3β Inhibitors Mimic the Cardioprotection Mediated by Ischemic Pre- and Postconditioning in Hypertensive Rats

Figure 8

(a) Typical traces produced by 200 μM Ca²⁺ addition to mitochondrial suspensions of the different experimental groups. (b) Mean values of the light scattering decreases (LSD) after Ca²⁺ addition, expressed in arbitrary units (a.u.), in nonischemic control (NIC), ischemic control (IC), preconditioned (PRE), postconditioned (POS), PRE+W (wortmannin), POS+W, lithium, and IMI treated hearts. The response of isolated mitochondria to Ca²⁺ was significantly diminished in IC hearts and was partially recovered after interventions and treatments. W abolished the favorable changes produced by PRE and POS. *𝑃<0.05 versus NIC; ^#𝑃<0.05 versus IC; ^ξ𝑃<0.05 versus PRE and POS.

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