DHA Inhibits Protein Degradation More Efficiently than EPA by Regulating the PPARγ/NFκB Pathway in C2C12 Myotubes
Figure 1
Effect of n-3 PUFA on total protein degradation in C2C12 myotubes. C2C12 myotubes were incubated (24 hours) with increasing concentrations of EPA (▲) or DHA (■), respectively. The radioactivity associated with cellular proteins is shown in the presence of 300 μM, 400 μM, 500 μM or 600 μM EPA, or DHA, respectively. Each treatment mean () reported as a percentage of a FFA-free control; bars, SE. a, differences from controls in the presence of EPA () and b, differences from the presence of DHA (). EPA = eicosapentaenoic acid, DHA = docosahexaenoic acid.
