TY - JOUR A2 - Wang, Sihe AU - Han, Tianzhao AU - Rong, Gong AU - Quan, Dayong AU - Shu, Ying AU - Liang, Zhu AU - She, Ninglan AU - Liu, Manli AU - Yang, Bing AU - Cheng, Gong AU - Lv, Yongman AU - Stern, Leonard PY - 2013 DA - 2012/12/27 TI - Meta-Analysis: The Efficacy and Safety of Paricalcitol for the Treatment of Secondary Hyperparathyroidism and Proteinuria in Chronic Kidney Disease SP - 320560 VL - 2013 AB - Introduction. Previous studies have demonstrated the safety and efficacy of using Paricalcitol for the treatment of secondary hyperparathyroidism (SHPT) in patients on dialysis. The aim of the current meta-analysis was to assess the safety and efficacy of Paricalcitol for the management of SHPT in patients with chronic kidney disease (CKD) not yet on dialysis. A secondary aim was to determine if sufficient data was available to assess the effect of Paricalcitol for the management of proteinuria. Methods. A meta-analysis was conducted using the Cochrane Collaboration’s RevMan 4.2 software. Results. Paricalcitol is effective in lowering PTH in patients with CKD not yet on dialysis and is also effective in lowering proteinuria in diabetic CKD patients. However, we uncovered a safety signal identifying an elevated calcium phosphate product and a trend towards the development of hypercalcemia. A phosphate elevation was not demonstrated because the target used in the clinical studies was a P>5.5 mg/dl, a value appropriate for dialysis patients and not CKD patients. Conclusion. Although Paricalcitol is effective in lowering PTH, we advise caution in the use of any active Vitamin D analogues in patients with CKD because of the potential risk of exacerbating vascular calcification. SN - 2314-6133 UR - https://doi.org/10.1155/2013/320560 DO - 10.1155/2013/320560 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -