TY - JOUR
A2 - Wang, Sihe
AU - Han, Tianzhao
AU - Rong, Gong
AU - Quan, Dayong
AU - Shu, Ying
AU - Liang, Zhu
AU - She, Ninglan
AU - Liu,
Manli
AU - Yang, Bing
AU - Cheng, Gong
AU - Lv, Yongman
AU - Stern, Leonard
PY - 2013
DA - 2012/12/27
TI - Meta-Analysis: The Efficacy and Safety of Paricalcitol for the Treatment of Secondary Hyperparathyroidism and Proteinuria in Chronic Kidney Disease
SP - 320560
VL - 2013
AB - Introduction. Previous studies have demonstrated the safety and efficacy of using Paricalcitol for the treatment of secondary hyperparathyroidism (SHPT) in patients on dialysis. The aim of the current meta-analysis was to assess the safety and efficacy of Paricalcitol for the management of SHPT in patients with chronic kidney disease (CKD) not yet on dialysis. A secondary aim was to determine if sufficient data was available to assess the effect of Paricalcitol for the management of proteinuria. Methods. A meta-analysis was conducted using the Cochrane Collaboration’s RevMan 4.2 software. Results. Paricalcitol is effective in lowering PTH in patients with CKD not yet on dialysis and is also effective in lowering proteinuria in diabetic CKD patients. However, we uncovered a safety signal identifying an elevated calcium phosphate product and a trend towards the development of hypercalcemia. A phosphate elevation was not demonstrated because the target used in the clinical studies was a P>5.5 mg/dl, a value appropriate for dialysis patients and not CKD patients. Conclusion. Although Paricalcitol is effective in lowering PTH, we advise caution in the use of any active Vitamin D analogues in patients with CKD because of the potential risk of exacerbating vascular calcification.
SN - 2314-6133
UR - https://doi.org/10.1155/2013/320560
DO - 10.1155/2013/320560
JF - BioMed Research International
PB - Hindawi Publishing Corporation
KW -
ER -