Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2013, Article ID 341218, 9 pages
http://dx.doi.org/10.1155/2013/341218
Research Article

Hp- -CD-Voriconazole In Situ Gelling System for Ocular Drug Delivery: In Vitro, Stability, and Antifungal Activities Assessment

Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala National Highway, Rajpura, Patiala, Punjab 140401, India

Received 6 March 2013; Revised 15 April 2013; Accepted 15 April 2013

Academic Editor: Rumiana Koynova

Copyright © 2013 Pravin Pawar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. F. Saettone, B. Giannaccini, A. Guiducci, F. Marca, and G. Tota, “Polymer effects on ocular bioavailability, II: the influence of benzalkonium chloride on the mydriatic response of tropicamide in different polymeric vehicles,” Int J Pharm, vol. 25, no. 73, 83 pages, 1985. View at Google Scholar
  2. J. W. Shell, “Ocular drug delivery systems—a review,” Cutaneous and Ocular Toxicol, vol. 1, pp. 49–63, 1982. View at Google Scholar
  3. J. R. Robinson, “Ocular drug delivery: mechanisms of corneal drug transport & mucoadhesive delivery systems,” STP Pharma, vol. 12, pp. 839–846, 1989. View at Google Scholar
  4. C. Le Bourlais, L. Acar, H. Zia, P. A. Sado, T. Needham, and R. Leverge, “Ophthalmic drug delivery systems—recent advances,” Progress in Retinal and Eye Research, vol. 17, no. 1, pp. 33–58, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. T. F. Patton and J. R. Robinson, “Ocular evaluation of polyvinyl alcohol vehicle in rabbits,” Journal of Pharmaceutical Sciences, vol. 64, no. 8, pp. 1312–1316, 1975. View at Google Scholar · View at Scopus
  6. M. F. Sattone, B. Ginnaccini, A. Tenzggi, and P. N. Tellini, “Vehicle effect on ophthalmic bioavailibility: the influence of different polymers on the activity of pilocarpine in rabbits and man,” Journal of Pharmacy and Pharmacology, vol. 34, pp. 464–466, 1982. View at Google Scholar
  7. H. W. Hui and J. R. Robinson, “Ocular delivery of progesterone using a bioadhesive polymer,” International Journal of Pharmaceutics, vol. 26, no. 3, pp. 203–213, 1985. View at Google Scholar · View at Scopus
  8. R. H. Gunny, A. A. Ibrahim, P. Duri, C. G. Wilson, and N. Washington, “Design and evaluation of controlled release system for the eye,” Journal of Controlled Release, vol. 6, pp. 367–373, 1987. View at Google Scholar
  9. S. Ding, “Recent developments in ophthalmic drug delivery,” Pharmaceutical Science & Technology Today, vol. 1, pp. 328–3235, 1998. View at Google Scholar
  10. M. J. Taravella, “Collagen shield delivery of ofloxacin to the human eye,” Journal of Cataract and Refractive Surgery, vol. 25, no. 4, pp. 562–565, 1999. View at Google Scholar · View at Scopus
  11. O. Séchoy, G. Tissié, C. Sébastian, F. Maurin, J. Y. Driot, and C. Trinquand, “A new long acting ophthalmic formulation of Carteolol containing alginic acid,” International Journal of Pharmaceutics, vol. 207, no. 1-2, pp. 109–116, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. N. A. Peppas, P. Bures, W. Leobandung, and H. Ichikawa, “Hydrogels in pharmaceutical formulations,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 50, pp. 27–46, 2000. View at Google Scholar
  13. L. E. Bromberg and E. S. Ron, “Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery,” Advanced Drug Delivery Reviews, vol. 31, no. 3, pp. 197–221, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. K. S. Soppimath, T. M. Aminabhavi, A. M. Dave, S. G. Kumbar, and W. E. Rudzinski, “Stimulus-responsive "smart" hydrogels as novel drug delivery systems,” Drug Development and Industrial Pharmacy, vol. 28, no. 8, pp. 957–974, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Ritter Jones and P. B. Messersmith, “In situ forming biomaterials,” Oral and Maxillofacial Surgery Clinics of North America, vol. 14, no. 1, pp. 29–38, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. T. R. Bhardwaj, M. Kanwar, R. Lal, and A. Gupta, “Natural gums and modified natural gums as sustained-release carriers,” Drug Development and Industrial Pharmacy, vol. 26, no. 10, pp. 1025–1038, 2000. View at Publisher · View at Google Scholar · View at Scopus
  17. J. H. Guo, G. W. Skinner, W. W. Harcum, and P. E. Barnum, “Pharmaceutical applications of naturally occurring water-soluble polymers,” Pharmaceutical Science and Technology Today, vol. 1, no. 6, pp. 254–261, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. I. R. Schmolka, “A review of block polymer surfactants,” Journal of the American Oil Chemists' Society, vol. 54, no. 3, pp. 110–116, 1977. View at Publisher · View at Google Scholar · View at Scopus
  19. J. C. Gilbert, J. L. Richardson, M. C. Davies, K. J. Palin, and J. Hadgraft, “The effect of solutes and polymers on the gelation properties of pluronic F-127 solutions for controlled drug delivery,” Journal of Controlled Release, vol. 5, no. 2, pp. 113–118, 1987. View at Google Scholar · View at Scopus
  20. H. G. Choi, J. H. Jung, J. M. Ryu, S. J. Yoon, Y. K. Oh, and C. K. Kim, “Development of In situ-gelling and mucoadhesive acetaminophen liquid suppository,” International Journal of Pharmaceutics, vol. 165, no. 1, pp. 33–44, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. N. V. Prajna, J. Mascarenhas, T. Krishnan et al., “Comparison of natamycin and voriconazole for the treatment of fungal keratitis,” Archives of Ophthalmology, vol. 128, no. 6, pp. 672–678, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. S. M. Hariprasad, W. F. Mieler, T. K. Lin, W. E. Sponsel, and J. R. Graybill, “Voriconazole in the treatment of fungal eye infections: a review of current literature,” British Journal of Ophthalmology, vol. 92, no. 7, pp. 871–878, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Davies, “Biopharmaceutical considerations in topical ocular drug delivery,” Clinical and Experimental Pharmacology and Physiology, vol. 27, pp. 558–562, 2000. View at Google Scholar
  24. A. Dupuis, N. Tournier, G. Le Moal, and N. Venisse, “Preparation and stability of voriconazole eye drop solution,” Antimicrobial Agents and Chemotherapy, vol. 53, no. 2, pp. 798–799, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. M. A. Halim Mohamed and A. A. Mahmoud, “Formulation of indomethacin eye drops via complexation with cyclodextrins,” Current Eye Research, vol. 36, no. 3, pp. 208–216, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. R. Nijhawan and S. P. Agarwal, “Development of an ophthalmic formulation containing ciprofloxacin-hydroxypropyl-b-cyclodextrin complex,” Bollettino Chimico Farmaceutico, vol. 142, no. 5, pp. 214–219, 2003. View at Google Scholar · View at Scopus
  27. R. R. Klont, C. A. Eggink, A. J. Rijs, P. Wesseling, and P. E. Verweij, “Successful treatment of Fusarium keratitis with cornea transplantation and topical and systemic voriconazole,” Clinical Infectious Diseases, vol. 40, no. 12, pp. 110–112, 2005. View at Google Scholar · View at Scopus
  28. D. S. Singhare, S. Khan, and P. G. Yeole, “Temperature induced In situ gel of lidocaine hydrochloride for periodontal anaesthsia,” Indian Drugs, vol. 42, no. 8, pp. 519–524, 2005. View at Google Scholar · View at Scopus
  29. D. Shastri, S. Prajapati, and L. Patel, “Thermoreversible mucoadhesive ophthalmic In situ hydrogel: design and optimization using a combination of polymers,” Acta Pharmaceutica, vol. 60, no. 3, pp. 349–360, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. E. E. Hassan and J. M. Gallo, “A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength,” Pharmaceutical Research, vol. 7, no. 5, pp. 491–495, 1990. View at Google Scholar · View at Scopus
  31. P. Costa and S. M. J. Lobo, “Modeling and comparison of dissolution profiles,” European Journal of Pharmaceutical Sciences, vol. 13, pp. 123–133, 2001. View at Google Scholar
  32. M. K. Pathak, G. Chhabra, and K. Pathak, “Design and development of a novel pH triggered nanoemulsified in-situ ophthalmic gel of fluconazole: ex-vivo transcorneal permeation, corneal toxicity and irritation testing,” Drug Development and Industrial Pharmacy, vol. 39, no. 5, pp. 780–790, 2013. View at Publisher · View at Google Scholar
  33. H. W. Bauer, W. M. M. Kirby, J. C. Slerris, and M. Truck, “Antibiotic susceptibility testing by a standardized single disc method,” American Journal of Clinical Pathology, vol. 45, pp. 493–496, 1996. View at Google Scholar
  34. “Q1A (R2): stability testing of new drug substances and products,” in Proceedings of the International Conference on Harmonization (ICH '03), Geneva, Switzerland, 2003.
  35. K. Edsman, J. Carlfors, and R. Petersson, “Rheological evaluation of poloxamer as an In situ gel for ophthalmic use,” European Journal of Pharmaceutical Sciences, vol. 6, no. 2, pp. 105–112, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Wei, H. Xu, P. T. Ding, S. M. Li, and J. M. Zheng, “Thermosetting gels with modulated gelation temperature for ophthalmic use: the rheological and gamma scintigraphic studies,” Journal of Controlled Release, vol. 83, no. 1, pp. 65–74, 2002. View at Publisher · View at Google Scholar · View at Scopus
  37. J. D. Smart, I. W. Kellaway, and H. E. C. Worthington, “An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery,” Journal of Pharmacy and Pharmacology, vol. 36, no. 5, pp. 295–299, 1984. View at Google Scholar · View at Scopus
  38. E. Y. Kim, Z. G. Gao, J. S. Park, H. Li, and K. Han, “rhEGF/HP-β-CD complex in poloxamer gel for ophthalmic delivery,” International Journal of Pharmaceutics, vol. 233, no. 1-2, pp. 159–167, 2002. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Qi, L. Li, C. Huang, W. Li, and C. Wu, “Optimization and physicochemical characterization of thermosensitive poloxamer gel containing puerarin for ophthalmic use,” Chemical and Pharmaceutical Bulletin, vol. 54, no. 11, pp. 1500–1507, 2006. View at Publisher · View at Google Scholar · View at Scopus
  40. J. D. Smart, I. W. Kellaway, and H. E. C. Worthington, “An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery,” Journal of Pharmacy and Pharmacology, vol. 36, no. 5, pp. 295–299, 1984. View at Google Scholar · View at Scopus
  41. Z. Liu, J. Li, S. Nie, H. Liu, P. Ding, and W. Pan, “Study of an alginate/HPMC-based In situ gelling ophthalmic delivery system for gatifloxacin,” International Journal of Pharmaceutics, vol. 315, no. 1-2, pp. 12–17, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. D. M. Maurice and M. V. Riley, “Ocular Pharmacokinetics,” in Biochemistry of the Eye, pp. 6–16, Graymore, London, UK, 1970. View at Google Scholar