Figure 3: Concentration-dependent effects of hesperidin, hesperetin, and naringenin on octanoate metabolism. Data were obtained from experiments similar to those illustrated in Figure 2. Values in the absence of citrus flavanones (control values) are the mean values before the onset of citrus flavanones infusion. Values in the presence of citrus flavanones were computed at the end of the citrus flavanone infusion. Each experimental point is the mean ± standard error of three animals (three liver perfusion experiments) for each experimental condition. Asterisks indicate a statistically significant difference compared to the control condition, as revealed by variance analysis with post hoc Newman-Keuls testing (* ).