Activation of the ERK1/2 Signaling Pathway during the Osteogenic Differentiation of Mesenchymal Stem Cells Cultured on Substrates Modified with Various Chemical Groups

Figure 10

Real-time RT-PCR analysis of the expression of osteogenesis-related genes in BMSCs cultured on the –NH₂- and –CH₃-modified substrates in the presence of 0, 10, 25, and 50 μM of PD98059 for 10 days. (a) Cbfα-1 and (b) ALP. ^☆𝑃<0.05 versus the respective –CH₃-modified substrate; ^◆𝑃<0.05 versus the 0 μM dose group.

(a)

(b)