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BioMed Research International
Volume 2013, Article ID 371819, 7 pages
http://dx.doi.org/10.1155/2013/371819
Clinical Study

Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study

1Department of Radiation and Medical Oncology, Zhongnan Hospital, Hubei Cancer Clinical Study Center, Wuhan University, Wuhan 430071, China
2Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangzhou 510060, China
3Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China

Received 10 March 2013; Accepted 14 April 2013

Academic Editor: An Liu

Copyright © 2013 Ming Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. E. Vokes, J. E. Herndon II, M. J. Kelley et al., “Induction chemotherapy followed by chemoradiotherapy compared with chemoradiotherapy alone for regionally advanced unresectable stage III non-small-cell lung cancer: cancer and leukemia group B,” Journal of Clinical Oncology, vol. 25, no. 13, pp. 1698–1704, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. J. D. Bradley, S. Wahab, M. A. Lockett, C. A. Perez, and J. A. Purdy, “Elective nodal failures are uncommon in medically inoperable patients with Stage I non-small-cell lung carcinoma treated with limited radiotherapy fields,” International Journal of Radiation Oncology * Biology * Physics, vol. 56, no. 2, pp. 342–347, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. K. E. Rosenzweig, S. Sura, A. Jackson, and E. Yorke, “Involved-field radiation therapy for inoperable non-small-cell lung cancer,” Journal of Clinical Oncology, vol. 25, no. 35, pp. 5557–5561, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. J. A. Hayman, M. K. Martel, R. K. Ten Haken et al., “Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial,” Journal of Clinical Oncology, vol. 19, no. 1, pp. 127–136, 2001. View at Google Scholar · View at Scopus
  5. F. M. Kong, R. K. Ten Haken, M. J. Schipper et al., “High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study,” International Journal of Radiation Oncology * Biology * Physics, vol. 63, no. 2, pp. 324–333, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. J. S. A. Belderbos, L. Kepka, F. M. (Spring) Kong F.-M., M. K. Martel, G. M. M. Videtic, and B. Jeremic, “Report from the International Atomic Energy Agency (IAEA) consultants' meeting on elective nodal irradiation in lung cancer: non-small-cell lung cancer (NSCLC),” International Journal of Radiation Oncology * Biology * Physics, vol. 72, no. 2, pp. 335–342, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Choy, H. Safran, W. Akerley, S. L. Graziano, J. A. Bogart, and B. F. Cole, “Phase II trial of weekly paclitaxel and concurrent radiation therapy for locally advanced non-small cell lung cancer,” Clinical Cancer Research, vol. 4, no. 8, pp. 1931–1936, 1998. View at Google Scholar · View at Scopus
  8. P. Giraud, M. Antoine, A. Larrouy et al., “Evaluation of microscopic tumor extension in non-small-cell lung cancer for three-dimensional conformal radiotherapy planning,” International Journal of Radiation Oncology * Biology * Physics, vol. 48, no. 4, pp. 1015–1024, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. J. D. Cox, J. Stetz, and T. F. Pajak, “Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC),” International Journal of Radiation Oncology * Biology * Physics, vol. 31, no. 5, pp. 1341–1346, 1995. View at Publisher · View at Google Scholar · View at Scopus
  10. J. Bradley, M. V. Graham, K. Winter et al., “Toxicity and outcome results of RTOG 9311: a phase I-II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma,” International Journal of Radiation Oncology * Biology * Physics, vol. 61, no. 2, pp. 318–328, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. N. J. Graham, K. J. M. Chan, U. Pastorino, and P. Goldstraw, “Systematic nodal dissection in the intrathoracic staging of patients with non-small cell lung cancer,” Journal of Thoracic and Cardiovascular Surgery, vol. 117, no. 2, pp. 246–251, 1999. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Koike, M. Terashima, T. Takizawa, T. Watanabe, Y. Kurita, and A. Yokoyama, “Clinical analysis of small-sized peripheral lung cancer,” Journal of Thoracic and Cardiovascular Surgery, vol. 115, no. 5, pp. 1015–1020, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. J. Wu, Y. Ohta, H. Minato et al., “Nodal occult metastasis in patients with peripheral lung adenocarcinoma of 2.0 cm or less in diameter,” Annals of Thoracic Surgery, vol. 71, no. 6, pp. 1772–1778, 2001. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Andratschke, F. Zimmermann, E. Boehm, S. Schill, C. Schoenknecht et al., “Stereotactic radiotherapy of histologically proven inoperable stage I non-small cell lung cancer: patterns of failure,” Radiotherapy and Oncology, vol. 101, no. 2, pp. 245–249, 2011. View at Google Scholar
  15. E. P. Sulman, R. Komaki, A. H. Klopp, J. D. Cox, and J. Y. Chang, “Exclusion of elective nodal irradiation is associated with minimal elective nodal failure in non-small cell lung cancer,” Radiation Oncology, vol. 4, article 5, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. D. De Ruysscher, S. Wanders, E. van Haren et al., “Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: a prospective clinical study,” International Journal of Radiation Oncology * Biology * Physics, vol. 62, no. 4, pp. 988–994, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. K. E. Rosenzweig, S. E. Sim, B. Mychalczak, L. E. Braban, R. Schindelheim, and S. A. Leibel, “Elective nodal irradiation in the treatment of non-small-cell lung cancer with three-dimensional conformal radiation therapy,” International Journal of Radiation Oncology * Biology * Physics, vol. 50, no. 3, pp. 681–685, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. J. S. A. Belderbos, W. D. Heemsbergen, K. De Jaeger, P. Baas, and J. V. Lebesque, “Final results of a phase I/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy,” International Journal of Radiation Oncology * Biology * Physics, vol. 66, no. 1, pp. 126–134, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. A. T. Fernandes, J. Shen, J. Finlay et al., “Elective nodal irradiation (ENI) versus involved field radiotherapy (IFRT) for locally advanced non-small cell lung cancer (NSCLC): a comparative analysis of toxicities and clinical outcomes,” Radiotherapy and Oncology, vol. 95, no. 2, pp. 178–184, 2010. View at Google Scholar · View at Scopus
  20. S. Yuan, X. Sun, M. Li et al., “A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer,” American Journal of Clinical Oncology, vol. 30, no. 3, pp. 239–244, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. S. A. Belderbos, K. De Jaeger, W. D. Heemsbergen et al., “First results of a phase I/II dose escalation trial in non-small cell lung cancer using three-dimensional conformal radiotherapy,” Radiotherapy and Oncology, vol. 66, no. 2, pp. 119–126, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Sura, C. Greco, D. Gelblum, E. D. Yorke, A. Jackson, and K. E. Rosenzweig, “(18)F-fluorodeoxyglucose positron emission tomography-based assessment of local failure patterns in non-small-cell lung cancer treated with definitive radiotherapy,” International Journal of Radiation Oncology * Biology * Physics, vol. 70, no. 5, pp. 1397–1402, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. R. Rengan, K. E. Rosenzweig, E. Venkatraman et al., “Improved local control with higher doses of radiation in large-volume stage III non-small-cell lung cancer,” International Journal of Radiation Oncology * Biology * Physics, vol. 60, no. 3, pp. 741–747, 2004. View at Publisher · View at Google Scholar · View at Scopus
  24. J. D. Bradley, R. Paulus, R. Komaki et al., “A randomized phase III comparison of standard-dose (60 Gy) versus high-dose (74 Gy) conformal chemoradiotherapy +/- cetuximab for stage IIIA/IIIB non-small cell lung cancer: preliminary findings on radiation dose in RTOG 0617,” in Proceedings of the 53rd Annual Meeting of the American Society of Radiation Oncology, Miami, Fla, USA, October 2011.
  25. J. D. Cox, “Are the results of RTOG, 0617 mysterious?” International Journal of Radiation Oncology * Biology * Physics, vol. 82, no. 3, pp. 1042–1044, 2012. View at Google Scholar
  26. E. M. Toloza, L. Harpole, and D. C. McCrory, “Noninvasive staging of non-small cell lung cancer: a review of the current evidence,” Chest, vol. 123, supplement 1, pp. 137S–146S, 2003. View at Google Scholar · View at Scopus
  27. R. J. Cerfolio, A. S. Bryant, and B. Ojha, “Restaging patients with N2 (stage IIIa) non-small cell lung cancer after neoadjuvant chemoradiotherapy: a prospective study,” Journal of Thoracic and Cardiovascular Surgery, vol. 131, no. 6, pp. 1229–1235, 2006. View at Publisher · View at Google Scholar · View at Scopus