Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance

Table 1

Receptors present on various hepatic cell and may be used for drug targeting [25].

Hepatocytes	Kupffer cells	Endothelial cell	Hepatic stellate cells
Asialoglycoprotein receptor (ASGP-R)	Mannose/N-acetyl glucose amine R	Mannose/N-acetyl glucose amine R	M6P/IGF II R
HDL-R	Galactose particle R	Scavenger R (Class A1 and A11)	𝛼2 macroglobulin R
LDL-R	Galactose specific R	Fc R immune complexes	Ferritin R
IgA-R	Fc R (immune complexes, opsonized material)	Matrix compound (hyaluronan fibronectin, denatured collagen PIIINP)	Uroplasminogen R
Scavenger R (Class BI)	Scavenger R (Class AI, BI, BII, MARCO CD36 and macrosialin)		Thrombin R
Transferrin R	LDL R matrix compounds (fibronectin)		RBP R matrix compounds (intregrin, collagen type VI, fibronectin CD44)
Insulin R	Complement R (C3b and C1q) LPS R α 2 macroglobulin R

*R: Receptor.