TY - JOUR A2 - Armstrong, David G. AU - Tsourdi, Elena AU - Barthel, Andreas AU - Rietzsch, Hannes AU - Reichel, Andreas AU - Bornstein, Stefan R. PY - 2013 DA - 2013/04/07 TI - Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus SP - 385641 VL - 2013 AB - Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care. SN - 2314-6133 UR - https://doi.org/10.1155/2013/385641 DO - 10.1155/2013/385641 JF - BioMed Research International PB - Hindawi Publishing Corporation KW - ER -