Dynamic of Mutational Events in Variable Number Tandem Repeats of Escherichia coli O157:H7
Table 2
Mutation rates and products for 9 E. coli O157:H7 strains.
Strains and loci
RU (bp)
a
Total no. of mutations
Mutation rate
No. of insertions
No. of deletions
Sb
Mc
Sb
Mc
HT2-15
TR4
6
99
1
4.3 × 10−05
0
1
0
0
O157-10
6
96
5
2.2 × 10−04
4
1
0
0
Total
6
2.6 ×
6
0
EDL933
Vhec7
7
99
2
8.6 × 10−05
2
0
0
0
TR3
6
97
1
4.4 × 10−05
1
0
0
0
TR4
6
97
1
4.4 × 10−05
1
0
0
0
TR7
6
97
1
4.4 × 10−05
1
0
0
0
O157-3
6
100
2
8.5 × 10−05
1
0
1
0
O157-10
6
100
3
1.3 × 10−04
0
2
0
1
Total
10
4.3 ×
8
2
FB3
O157-10
6
90
8
3.8 × 10−04
1
2
3
2
Total
8
3.8 ×
3
5
Mat167/6
TR4
6
100
1
4.3 × 10−05
0
0
1
0
O157-10
6
100
6
2.5 × 10−04
0
5
1d
0
O157-37
6
100
1
4.3 × 10−05
1
0
0
0
Total
8
3.4 ×
6
2
Gal 26
O157-37
6
100
1
4.3 × 10−05
0
0
0
1
Total
1
4.3 ×
0
1
FC O157
Vhec4
6
100
1e
4.3 × 10−05
0
0
0
0
TR7
6
100
2
8.5 × 10−05
0
0
2
0
O157-10
6
89
10
4.8 × 10−04
1
3
0
6
Total
13
7.1 ×
4
8
FB22
O157-10
6
92
5
2.3 × 10−04
1
1
3
0
Total
5
2.3 ×
2
3
FB81
Vhec4
6
92
1
4.6 × 10−05
1
0
0
0
Total
1
4.6 ×
1
0
665p
Vhec4
6
100
1
4.3 × 10−05
1
0
0
0
O157-10
6
100
4
1.7 × 10−04
2
0
0
2
Total
5
2.1 ×
3
2
Combined data for the nine PSPEs
Insertions
Deletions
Sb
Mc
Sb
Mc
Vhec4
97.3
3
1.3 × 10−04
2
0
0
0
Vhec7
99
2
8.6 × 10−05
2
0
0
0
TR3
97
1
4.4 × 10−05
1
0
0
0
TR4
98.7
3
1.3 × 10−04
1
1
1
0
TR7
98.5
3
1.3 × 10−04
1
0
2
0
O157-3
100
2
8.5 × 10−05
1
0
1
0
O157-10
95.3
41
1.8 × 10−03
9
14
7
11
O157-37
100
2
8.5 × 10−05
1
0
0
1
18
15
11
12
Total
57
2.5 ×
33
23
Number of lineages with usable data.
bSingle repeat mutation.
cMultiple repeat mutation.
dDeletion of one TR and insertion of 36 pb aleatory sequence.
ePoint mutation.
