A Combination of Radiosurgery and Soluble Tissue Factor Enhances Vascular Targeting for Experimental Glioblastoma

Figure 5

Survival rate and body weight of GBM mice. Forty GBM mice were randomly divided into 5 groups and received coadministration of soluble tissue factor and lipopolysaccharide (TF + PLS) or a combination of radiosurgery and soluble tissue factor plus lipopolysaccharide (TF + PLS + Ra), soluble tissue factor (TF + Ra) lipopolysaccharide (PLS + Ra), and saline (PBS + Ra), respectively. Animals were i.v. injected with different agents 24 hours following a 6 Gray radiosurgery. (a) TF + PLS + Ra treatment delivered the highest survival rate of GBM mice. TF + Ra group produced a higher survival rate than TF + LPS group. No animal survived more than 17 days in PBS + Ra and PLS + Ra groups. (b) Body weight of TF + PLS + Ra group was increased with time over a period of 30 days (𝑟=0.8783,  𝑃<0.0001). Animal body weight in TF + Ra, TF + LPS, LPS + Ra, and PBS + Ra was declined with time (𝑟=−0.5616,  𝑃<0.0005; 𝑟=−0.9453,  𝑃<0.001; 𝑟=−0.9322,  𝑃<0.001; 𝑟=−0.9578,  𝑃<0.001, resp.).

(a)  

(b)