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BioMed Research International
Volume 2013, Article ID 392010, 5 pages
http://dx.doi.org/10.1155/2013/392010
Research Article

Comparative Plasma Exposure and Lung Distribution of Two Human Use Commercial Azithromycin Formulations Assessed in Murine Model: A Preclinical Study

1Laboratory of Pharmacology, Faculty of Veterinary Medicine, Universidad Nacional del Centro de la Provincia de Buenos Aires, Paraje Arroyo Seco s/n., 7000 Tandil, Argentina
2Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Argentina
3Tandil Veterinary Research Center (CIVETAN-CONICET), Argentina

Received 30 April 2013; Revised 3 July 2013; Accepted 24 July 2013

Academic Editor: Kazim Husain

Copyright © 2013 Virginia Rivulgo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Guiguére, S. Jacks, and G. Roberts, “Retrospective comparison azithromycin, claritromycin and erythromycin for treatmeant of foals with Rodococcus equi pneumonia,” Journal of Veterinary Internal Medicine, vol. 18, pp. 568–573, 2004. View at Google Scholar
  2. R. Danesi, A. Lupetti, C. Barbara et al., “Comparative distribution of azithromycin in lung tissue of patients given oral daily doses of 500 and 1000 mg,” Journal of Antimicrobial Chemotherapy, vol. 51, no. 4, pp. 939–945, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. T. S. Armstrong, S. Choi, J. Walker, and M. R. Gilbert, “Seizure risk in brain tumor patients with conversion to generic Levetiracetam,” Journal of Neuro-Oncology, vol. 98, no. 1, pp. 137–141, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. D. Privitera, “Generic antiepileptic drugs: current controversies and future directions,” Epilepsy Currents, vol. 8, no. 5, pp. 113–117, 2008. View at Publisher · View at Google Scholar
  5. J. Gómez, A. M. Kanner, J. L. Herranz, A. Molins, and A. Gil-Nagel, “Risks and benefits of generic antiepileptic drugs,” Neurologist, vol. 14, supplement 1, no. 6, pp. S66–S72, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. A. P. Kumar and J. H. Park, “Azithromycin as a new chiral selector in capillary electrophoresis,” Journal of Chromatography A, vol. 1218, no. 9, pp. 1314–1317, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. A. Wildfeuer, H. Laufen, and T. Zimmermann, “Uptake of azithromycin by various cells and its intracellular activity under in vivo conditions,” Antimicrobial Agents and Chemotherapy, vol. 40, no. 1, pp. 75–79, 1996. View at Google Scholar · View at Scopus
  8. A. E. Girard, C. R. Cimochowski, and J. A. Faiella, “Correlation of increased azithromycin concentrations with phagocyte infiltration into sites of localized infection,” Journal of Antimicrobial Chemotherapy, vol. 37, pp. 9–19, 1996. View at Google Scholar · View at Scopus
  9. K. Togami, S. Chono, and K. Morimoto, “Transport characteristics of clarithromycin, azithromycin and telithromycin, antibiotics applied for treatment of respiratory infections, in Calu-3 cell monolayers as model lung epithelial cells,” Pharmazie, vol. 67, no. 5, pp. 389–393, 2012. View at Google Scholar
  10. A. J. Hutt and J. O'Grady, “Drug chirality: a consideration of the significance of the stereochemistry of antimicrobial agents,” Journal of Antimicrobial Chemotherapy, vol. 37, no. 1, pp. 7–32, 1996. View at Publisher · View at Google Scholar · View at Scopus
  11. D. B. Kell, P. D. Dobson, E. Bisland, and S. G. Oliver, “The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (nedd to) know and how we can do so,” Drug Discovery Today, vol. 18, no. 5-6, pp. 218–239, 2013. View at Google Scholar
  12. D. B. Kell, P. D. Dobson, and S. G. Oliver, “Pharmaceutical drug transport: the issues and the implications that it is essentially carrier-mediated only,” Drug Discovery Today, vol. 16, no. 15-16, pp. 704–714, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Mastoraki, A. Michalopoulos, I. Kriaras et al., “Incidence of postoperative infections in patients undergoing coronary artery bypass grafting surgery receiving antimicrobial prophylaxis with original and generic cefuroxime,” Journal of Infection, vol. 56, no. 1, pp. 35–39, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. A. F. Zuluaga, M. Agudelo, J. J. Cardeño, C. A. Rodriguez, and O. Vesga, “Determination of therapeutic equivalence of generic products of gentamicin in the neutropenic mouse thigh infection model,” PLoS ONE, vol. 5, no. 5, Article ID e10744, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. A. R. Breier, C. V. Garcia, T. P. Oppe, M. Steppe, and E. E. S. Schapoval, “Microbiological assay for azithromycin in pharmaceutical formulations,” Journal of Pharmaceutical and Biomedical Analysis, vol. 29, no. 5, pp. 957–961, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Gibaldi and D. Perrier, “Estimation of areas,” in Pharmacokinetics, M. Dekker, Ed., pp. 445–449, New York, NY, USA, 1982. View at Google Scholar
  17. E. Garver, E. D. Hugger, S. P. Shearn et al., “Involvement of intestinal uptake transporters in the absorption of azithromycin and clarithromycin in the rat,” Drug Metabolism and Disposition, vol. 36, no. 12, pp. 2492–2498, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. O. Vesga, M. Agudelo, B. E. Salazar, C. A. Rodriguez, and A. F. Zuluaga, “Generic vancomycin products fail in vivo despite being pharmaceutical equivalents of the innovator,” Antimicrobial Agents and Chemotherapy, vol. 54, no. 8, pp. 3271–3279, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. J. D. Henderson and R. H. Esham, “Generic substitution: issues for problematic drugs,” Southern Medical Journal, vol. 94, no. 1, pp. 16–21, 2001. View at Google Scholar · View at Scopus