IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
Table 2
Sociodemographics, clinics, and ancestry characteristics.
Variables
Low risk AI (711)
Medium risk AI (728)
High risk AI (56)
P value
Age
48.17 ± 8.61
46.86 ± 7.98
44.68 ± 7.98
0.0009*
Total cholesterol (mg/dL)
190.93 ± 39.92
222.63 ± 51.35
261.84 ± 65.86
0.0001*
LDL-c (mg/dL)
119.21 ± 30.88
140.08 ± 37.32
156.14 ± 50.88
0.0001*
HDL-c (mg/dL)
49.93. ± 12.97
38.89 ± 10.44
29.59 ± 7.36
0.0001*
Triglycerides (mg/dL)
158.95 ± 77.54
263.56 ± 160.32
361.75 ± 246.11
0.0001*
Disease status (%)
Health
45.71
28.16
30.36
<0.0001**
Metabolic syndrome
17.02
39.56
39.29
Type 2 diabetes
37.37
32.28
30.36
BMI
28.75 ± 4.47
29.15 ± 4.14
29.48 ± 5.43
0.07*
SBP (mm Hg)
119.28 ± 13.42
120.65 ± 12.33
119.21 ± 10.79
0.03*
DBP (mm Hg)
75.5 ± 8.63
76.10 ± 8.15
77.46 ± 7.99
0.21*
Glucose (mg/dL)
118.41 ± 56.90
127.29 ± 72.19
120.14 ± 56.96
0.07*
Insulin (pmol/L)
11.73 ± 8.89
12.27 ± 7.28
13.44 ± 9.23
0.009*
HOMA-IR
3.73 ± 5.23
4.07 ± 4.96
4.20 ± 4.32
0.005*
Ancestry contribution
African
0.03 ± 0.021
0.03 ± 0.023
0.03 ± 0.030
0.69*
European
0.32 ± 0.11
0.33 ± 0.10
0.32 ± 0.09
0.58*
Amerindian
0.65 ± 0.12
0.64 ± 0.11
0.65 ± 0.10
0.55*
Sex (%)
F
47.12
40.66
57.14
0.007**
M
52.88
59.34
42.86
Educational level (%)
Elementary or lower
31.16
30.70
31.91
0.88**
Middle school
27.08
28.07
31.91
High school
19.21
20.61
21.28
College or higher
22.54
20.61
14.89
Data shown in means and SD. F: female, M: male, SBP: systolic blood pressure, DBP: diastolic blood pressure. *Kruskal Wallis P value, **Chi square P value.
