IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population

Table 3

Genotype frequencies and Hardy-Weinberg equilibrium.

	Medium risk AI		High risk AI		Controls
	𝑛	%	𝑛	%	𝑛	%
IRS1 (rs1801278) Gly972Arg
G/G	6570	92.46	477	90.4	6377	92.70
G/A	51	7.17	5	9.6	49	7.13
A/A	3	0.42	0	0	1	0.14
G		0.96		0.96		0.95
A		0.04		0.04		0.05
HW* (P value)						0.95
TCF7L2 (rs12255372)
G/G	507	74.99	343	70.8	512	75.85
G/T	156	23	131	27.1	149	22.10
T/T	14	2.1	1	2.1	14	2.07
G		0.86		0.85		0.87
T		0.13		0.15		0.12
HW (P value)						0.42
TCF7L2 (rs7903146)
C/C	477	72.96	33	66	466	72.83
C/T	179	23.47	12	24	180	24.58
T/T	24	3.57	5	10	22	2.59
C		0.83		0.78		0.83
T		0.17		0.25		0.17
HW (P value)						0.17
PPARG (rs1801282) Pro12Ala
C/C	556	78.2	37	78.7	502	73.8
C/G	142	20	8	17	159	23.4
G/G	13	1.8	2	4.2	19	2.8
C		0.88		0.87		0.86
G		0.12		0.13		0.14
HW (P value)						0.14
ADRB1 (rs1801253) Arg389Gly
C/C	555	76.6	32	57.1	557	78.8
C/G	157	21.75	23	41.1	144	20.4
G/G	12	1.6	1	1.8	6	0.8
C		0.88		0.78		0.89
G		0.12		0.22		0.11
HW (P value)						0.31
HHEX (rs5015480)
T/T	267	37.8	18	32.7	266	37.36
T/C	341	48.3	28	50.9	316	47.93
C/C	98	13.9	9	16.4	93	14.71
T		0.62		0.58		0.61
C		0.38		0.42		0.38
HW (P value)						0.95

∗HW: Hardy-Weinberg equilibrium.