IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population
Table 4
Association of polymorphisms with atherogenic index.
SNP
Medium risk AI
P
High risk AI
P
ORa (CI)
ORa (CI)
IRS1 rs1801279
Log additive
1.00 (0.68, 1.47)
0.99
1.24 (0.49, 3.13)
0.65
TCF7L2 rs12255372
Log additive
0.95 (0.76, 1.19)
0.67
1.15 (0.64, 2.08)
0.63
TCF7L2 rs7903146
Log additive
0.93 (0.76, 1.15)
0.51
1.35 (0.82, 2.21)
0.24
PPARG rs1801282
Log additive
0.81 (0.65, 1.01)
0.06
0.89 (0.48, 1.65)
0.71
ADRB1 rs1801253
Log additive
1.16 (0.91, 1.47)
0.22
2.52 (1.54, 4.15)
<0.0001*
HHEX rs5015480
Log additive
1.03 (0.88, 1.22)
0.68
1.24 (0.82, 1.87)
0.30
Adjusted for age, sex, BMI, disease status, and ancestry percentage. IA Low risk was the reference category. *Bonferroni corrected P value threshold . Bold text denotes significant P values (<0.05).