IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population

Table 4

Association of polymorphisms with atherogenic index.

SNP	Medium risk AI	P	High risk AI	P
	ORa (CI)		ORa (CI)
IRS1 rs1801279
Log additive	1.00; (0.68, 1.47)	0.99	1.24; (0.49, 3.13)	0.65
TCF7L2 rs12255372
Log additive	0.95; (0.76, 1.19)	0.67	1.15; (0.64, 2.08)	0.63
TCF7L2 rs7903146
Log additive	0.93; (0.76, 1.15)	0.51	1.35; (0.82, 2.21)	0.24
PPARG rs1801282
Log additive	0.81; (0.65, 1.01)	0.06	0.89; (0.48, 1.65)	0.71
ADRB1 rs1801253
Log additive	1.16; (0.91, 1.47)	0.22	2.52; (1.54, 4.15)	<0.0001*
HHEX rs5015480
Log additive	1.03; (0.88, 1.22)	0.68	1.24; (0.82, 1.87)	0.30

Adjusted for age, sex, BMI, disease status, and ancestry percentage. IA Low risk was the reference category. *Bonferroni corrected P value threshold 𝑃≤0.004.
Bold text denotes significant P values (<0.05).