Development of Multiexon Skipping Antisense Oligonucleotide Therapy for Duchenne Muscular Dystrophy

Figure 1

Intron sizes around exons 45–55 of the DMD gene. The intron size of exon 44 (intron 44) is 248,400 nucleotides; subsequent introns are shorter from 2,300 to 54,200 nucleotides, until intron 55, which is 120,200 nucleotides. Interestingly, we and another group have detected very minimal spontaneous exons 45–55 skipping at low frequency in mouse and human cells.