In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product

Table 10

Serum HPCIII value at the end of the 4th, 8th, and 12th weeks in chronic toxicity assays (ng/mL).

Weeks	Female			Male
	4th	8th	12th	4th	8th	12th
I	3.39	0.974	3.16	9.14	2.27	1.15
II	1.38	1.48	3.71	2.48	0.528	ND
III	1.32	0.758	1.44	8.05	2.45	3.96
IV	0.986	3.10	1.10	1.16	10.8	8.46
V	7.05	1.71	3.96	9.43	55.7	None
VI	6.63	8.38	1.74	7.46	46.0	7.21
VII	3.91	1.33	0.757	1.57	6.50	8.68

None of the results were obtained in Group V male rats due to the fact that all rats were dead at the end of the 10th week.
ND: not detected.