In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product

Table 4

Mice grouping, treatments, and responses in acute toxicity testing.

Groups	Treatment	Dosage; (g/kg)	Male		Female
			Mortality	Symptoms and signs	Mortality	Symptoms and signs
A	Physiological saline	0	0	None	0	None
B	Water extraction of XF	16.68	0	None	0	None
C	Water extraction of XF	166.8	0	Slow respiratory frequency (20%), slow action (20%)	0	Salivation (20%), piloerection (20%), fast respiratory frequency (20%), slow action (20%)
D	Water extraction of XF	400	80%	Vomiting (20%), writhing reaction (20%), fast respiratory frequency (20%), convulsions (20%)	80%	Pupil dilation (20%), piloerection (20%), convulsions (20%)
E	Water extraction of PXF	16.68	0	None	0	None
F	Water extraction of PXF	166.8	0	Dark hair (20%), salivation (20%)	0	Convulsions (20%), salivation (20%)
G	Water extraction of PXF	400	40%	Convulsions (20%), salivation (20%)	40%	Convulsions (20%)