BioMed Research International / 2013 / Article / Tab 6

Research Article

In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product

Table 6

Rats mortality in chronic toxicity assays.

GroupsTreatmentMortality
FemaleMale

IPhysiological salineNoneNone

IIWater extraction of XFNone1. One dead at the 12 W + 3 D with 266 g BW (BW reduced gradually).

IIIWater extraction of XF1. One dead immediately after the blood sample collection procedure 2 W + 1 D.
2. Another one dead due to excessive anesthesia at the 8 W + 1 D.
1. One dead at the 11 W + 3 D with 340 g BW (BW reduced gradually).
2. One dead at the 11 W + 4 D with 261 g BW (BW reduced gradually).
3. Another one dead immediately after the blood sample collection procedure at the 3 W + 1 D.

IVWater extraction of XF1. One dead at the 10 W + 7 D with 170 g BW (BW reduced gradually).None

VWater extraction of PXF1. One dead at the 10 W + 2 D with 248 g BW (normal BW).
2. Another one dead immediately after the blood sample collection procedure at the 3 W + 1 D.
1. One dead immediately after the blood sample collection procedure at the 10 W + 1 D.
2–4. The other three rats were dead at the 7 W + 6 D (283 g BW), 9 W + 4 D (281 g BW), and 10 W + 4 D (242 g BW), respectively. Their BWs were reduced gradually.

VIWater extraction of PXF1. One dead at the 12 W + 1 D with 271 g BW (normal BW).
2. Another one dead immediately after the blood sample collection procedure at the 2 W + 1 D.
1. One dead immediately after the blood sample collection procedure at the 2 W + 1 D.

VIIWater extraction of PXF1. One dead at the 2 W + 6 D with 152 g BW (BW reduced dramatically).
2. Another one dead due to excessive anesthesia at the 8 W + 1 D.
1. One dead immediately after the blood sample collection procedure at the 6 W + 1 D.

Total911

BW: body weight.
2 W + 1 D: the first day of the second week, and so forth.
Deaths of these rats might be most probably related to the experimental operations.
Deaths of these rats might be most probably related to the administrations of XF and PXF.

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