In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product
Table 6
Rats mortality in chronic toxicity assays.
Groups
Treatment
Mortality
Female
Male
I
Physiological saline
None
None
II
Water extraction of XF
None
1▲. One dead at the 12 W + 3 D with 266 g BW (BW reduced gradually).
III
Water extraction of XF
1△. One dead immediately after the blood sample collection procedure 2 W + 1 D. 2△. Another one dead due to excessive anesthesia at the 8 W + 1 D.
1▲. One dead at the 11 W + 3 D with 340 g BW (BW reduced gradually). 2▲. One dead at the 11 W + 4 D with 261 g BW (BW reduced gradually). 3△. Another one dead immediately after the blood sample collection procedure at the 3 W + 1 D.
IV
Water extraction of XF
1△. One dead at the 10 W + 7 D with 170 g BW (BW reduced gradually).
None
V
Water extraction of PXF
1▲. One dead at the 10 W + 2 D with 248 g BW (normal BW). 2△. Another one dead immediately after the blood sample collection procedure at the 3 W + 1 D.
1△. One dead immediately after the blood sample collection procedure at the 10 W + 1 D. 2–4▲. The other three rats were dead at the 7 W + 6 D (283 g BW), 9 W + 4 D (281 g BW), and 10 W + 4 D (242 g BW), respectively. Their BWs were reduced gradually.
VI
Water extraction of PXF
1▲. One dead at the 12 W + 1 D with 271 g BW (normal BW). 2△. Another one dead immediately after the blood sample collection procedure at the 2 W + 1 D.
1△. One dead immediately after the blood sample collection procedure at the 2 W + 1 D.
VII
Water extraction of PXF
1▲. One dead at the 2 W + 6 D with 152 g BW (BW reduced dramatically). 2△. Another one dead due to excessive anesthesia at the 8 W + 1 D.
1△. One dead immediately after the blood sample collection procedure at the 6 W + 1 D.
Total
9
11
BW: body weight. 2 W + 1 D: the first day of the second week, and so forth. △Deaths of these rats might be most probably related to the experimental operations. ▲Deaths of these rats might be most probably related to the administrations of XF and PXF.
