In Vitro Cytotoxicity and In Vivo Acute and Chronic Toxicity of Xanthii Fructus and Its Processed Product

Table 8

Serum HA value at the end of the 4th, 8th, and 12th weeks in chronic toxicity assays (ng/mL).

Weeks	Female			Male
	4th	8th	12th	4th	8th	12th
I	80.2	53.7	55.3	94.0	56.7	57.3
II	60.7	61.9	60.8	61.5	57.2	60.1
III	106	56.8	58.4	64.8	60.2	61.6
IV	53.0	62.3	52.0	55.9	61.5	53.2
V	54.1	57.9	62.2	227	509	None
VI	208	53.5	61.3	56.9	87.3	53.3
VII	76.2	59.0	58.5	61.2	52.8	53.1

None of the results were obtained in Group V male rats due to the fact that all rats were dead at the end of the 10th week.