The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

Table 3

Stratification of MnSOD by CAT,  iNOS by CAT, smoking by GSTM1, smoking by iNOS, and cumulative asbestos exposure (>11.23 versus ≤11.23) by iNOS.

	OR	95% CI	𝑃 value
Stratification of MnSOD by CAT
Crude	0.67	0.44–1.01	0.047
CAT −262 TT	2.67	0.57–13.07	0.004
MnSOD −9Ala/Val + Val/Val versus Ala/Ala
CAT −262 CT + CC	0.59	0.38–0.93
MnSOD −9Ala/Val + Val/Val versus Ala/Ala
Stratification of iNOS by CAT
Crude	1.20	0.85–1.69	0.312
CAT −262 TT	5.14	1.30–20.36	0.000
iNOS LL versus SL + SS
CAT −262 CT + CC	1.08	0.75–1.55
iNOS LL versus SL + SS
Stratification of smoking by GSTM1
Crude	0.98	0.69–1.39	0.357
GSTM1-null	1.48	0.92–2.39	0.009
Smoking: ever versus never
GSTM1-present	0.55	0.31–1.00
Smoking: ever versus never
Stratification of smoking by iNOS
Crude	0.98	0.69–1.39	0.357
iNOS LL	1.39	0.84–2.30	0.050
Smoking: ever versus never
iNOS SL + SS	0.70	0.43–1.31
Smoking: ever versus never
Stratification of cumulative asbestos exposure (>11.23 versus ≤11.23) by iNOS
Crude	4.40	3.01–6.42	0.000
iNOS LL	3.09	1.81–5.25	0.000
Cumulative exposure: >11.23 versus ≤11.23
iNOS SL + SS	5.74	3.30–9.99
Cumulative exposure: >11.23 versus ≤11.23