The Influence of Gene-Gene and Gene-Environment Interactions on the Risk of Asbestosis

Table 4

Logistic regression analysis: interactions between MnSOD and CAT, iNOS and CAT,  GSTM1 and smoking, iNOS and smoking, and iNOS and log-cumulative asbestos exposure.

	OR	95% CI	𝑃 value
MnSOD −9Ala/Val + Val/Val versus Ala/Ala	0.59	0.39–0.91	0.016
CAT −262 TT versus CT + CC	0.53	0.17–1.62	0.266
Interaction^†	4.49	1.08–18.61	0.038
iNOS LL versus SL + SS	1.08	0.75–1.55	0.687
CAT −262 TT versus CT + CC	0.63	0.24–1.66	0.354
Interaction^‡	4.78	1.15–19.81	0.031
GSTM1-null versus present	0.63	0.39–1.02	0.062
Smoking	0.55	0.32–0.96	0.036
Interaction^#	2.67	1.31–5.46	0.007
iNOS LL versus SL + SS	0.85	0.53–1.37	0.505
Smoking	0.70	0.43–1.13	0.143
Interaction^§	2.00	0.99–4.03	0.054
iNOS LL versus SL + SS	1.91	1.07–3.42	0.030
Log cumulative exposure	4.25	2.79–6.46	0.000
Interaction*	0.55	0.31–0.97	0.037

†Interaction: MnSOD −9Ala/Val + Val/Val versus Ala/Ala ∗CAT −262 TT versus CT + CC.
‡Interaction: iNOS LL versus SL + SS ∗CAT −262 TT versus CT + CC.
#Interaction: GSTM1-null versus present ∗smoking (ever/never). §Interaction: iNOS LL versus SL + SS ∗smoking (ever/never).
∗Interaction: iNOS LL versus SL + SS ∗log cumulative exposure.