Role of STAT3 in Cancer Metastasis and Translational Advances

Table 1

Phenotype of STATs knockout mice.

Targeted gene	Phenotype
STAT1	Compromised innate response to microbial pathogens; and viruses.
STAT2	Increased susceptibility to viral infection and a loss; of biological response to type I IFN.
STAT3	Early embryonic lethality.
STAT4	Impaired natural killer cell cytotoxicity and Th1 cell; response.
STAT5a and 5b	No mammary gland development or lactogenesis.
STAT6	No Th2 cells development.