The Protective Effect of Fasudil on the Structure and Function of Cardiac Mitochondria from Rats with Type 2 Diabetes Induced by Streptozotocin with a High-Fat Diet Is Mediated by the Attenuation of Oxidative Stress
Effects of fasudil on the mitochondria of hearts from diabetic rats. The mitochondria of heart tissues were detected by TEM from the left ventricle of the rats. (a) Untreated diabetic group, 2,500x; (b) untreated diabetic group, 6,500x; (c) fasudil-treated diabetic group, 2,500x; (d) fasudil-treated diabetic group, 6,500x; (e) control group, 2,500x; (f) control group, 6,500x. Several mitochondria (M) exhibited swelling, enlargement, and diffuse edema, and disordered and partially disrupted mitochondrial cristae were observed in mitochondria from untreated diabetic rats. The damage to myocardial ultrastructures in fasudil-treated rats was attenuated compared with that of the untreated diabetic group.