Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction

Figure 2

Hypothesis accounting for the acute myocardial infarct size occurring in ischemia-reperfusion through molecular models based on the role of oxidative stress. Abrogation of the deleterious processes by vitamins C and E. Arrow color code: blue stands for “promotion”; yellow for “inhibition”: mPTP mitochondrial permeability transition pore; NO; nitric oxide; eNOS; endothelial nitric oxide synthase; NADPH, reduced nicotinamide adenine dinucleotide phosphate; NADPH ox, oxidized nicotinamide adenine dinucleotide phosphate; Nrf2, nuclear factor (erythroid-derived 2)-like 2. Adapted from [15], with permissions.