Research Article

Chromogenic In Situ Hybridization and p16/Ki67 Dual Staining on Formalin-Fixed Paraffin-Embedded Cervical Specimens: Correlation with HPV-DNA Test, E6/E7 mRNA Test, and Potential Clinical Applications

Figure 1

CISH positive signals. Diffuse pattern, where nuclei are completely stained ((a), 20x magnification). Punctated pattern in invasive squamous cervical cancer: distinct dot-like intranuclear signals were noted within cells infiltrating the stroma ((b), 100x magnification). Mixed patterns, where both diffuse and punctated signals are noted ((c), 40x magnification).
453606.fig.001a
(a)
453606.fig.001b
(b)
453606.fig.001c
(c)