The Fc Receptor Polymorphisms and Expression of Neutrophil Activation Markers in Patients with Sickle Cell Disease from Western India

Table 4

Distribution of the H and R alleles of FcγRIIA and NA1 and NA2 alleles of FcγRIIIB in sickle cell disease patients.

Group	Number of cases	FcγRIIA			FcγRIIIB
		H/H; Number (%)	H/R; Number (%)	R/R; Number (%)	NA1/NA1; Number (%)	NA1/NA2; Number (%)	NA2/NA2; Number (%)
SCD-mild	110	20 (18.2)	36 (32.7)	54 (49.1)	2 (1.8)	55 (50)	53 (48.2)
SCD-severe	75	23 (30.7)	25 (33.3)	27 (36)	0 (0)	48 (64)	27 (36)
SCD-total	185	43 (23.3)	61 (32.9)	81 (43.8)	2 (1.1)	103 (55.7)	80 (43.2)
Normals	175	28 (16)	82 (46.9)	65 (37.1)	22 (12.6)	90 (51.4)	63 (36)
^∗𝑃 value SCD Total versus normals		0.085	0.0074	0.2	0.0006	0.4194	0.1608
^∗𝑃 value SCD Mild versus Normals		0.632	0.019	0.0471	0.006	0.8143	0.0064
^∗𝑃 value; SCD Severe versus Normals		0.0172	0.0489	0.8637	0.03	0.0682	1.000

∗Chi-square test analysis comparing the FcγRIIA and FcγRIIIB gene frequencies in various groups.