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BioMed Research International
Volume 2013, Article ID 458278, 9 pages
Research Article

Transcriptional Response of Bovine Monocyte-Derived Macrophages after the Infection with Different Argentinean Mycobacterium bovis Isolates

1Biotechnology Institute, INTA Castelar, N. Repetto y Los Reseros s/n (1686), 1712 Hurlingham, Buenos Aires, Argentina
2Agricultural Microbiology, College of Agronomy, University of Buenos Aires, INBA-CONICET, Avenue San Martín 4453, C1417DSE Buenos Aires, Argentina

Received 6 August 2012; Revised 13 November 2012; Accepted 27 November 2012

Academic Editor: Frederick D. Quinn

Copyright © 2012 Karina Caimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

S1. The list of differentially expressed bovine macrophage transcripts detected post infection with M. bovis virulent and attenuated strain vs control uninfected cells.

S2. Functional clustering of differentially expressed bovine macrophage transcripts. The probesets differentially expressed in macrophage cells infected with the virulent and the attenuated strains versus the control cells were submitted to the DAVID web application for their functional clustering. The top ranking functional categories identified by DAVID are listed according to P-values. Cells infected with the virulent strain vs control cells rendered one functional cluster. Cells infected with the attenuated strain vs. control cells rendered 7 different clusters.

  1. Supplementary Material