Synthesis and Biological Evaluation of O-[3-¹⁸F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents

Figure 1

Synthetic scheme of FPAMT. The KF and kryptofix complex were incubated with N-t-butoxycarbonyl-O-[3-tosylpropyl]-α-methyl tyrosine ethyl ester (compound 1) in acetonitrile for synthesis of N-t-butoxycarbonyl-O-[3-¹⁹F-fluoropropyl]-α-methyl tyrosine ethyl ester (compound 2). After deprotection of butoxycarbonyl (BOC) of compound 2, O-[3-¹⁹F-fluoropropyl]-α-methyl tyrosine ethyl ester (compound 3) was synthesized. The final step is to yield FPAMT (compound 4) by deesterification of compound 3.