Synthesis and Biological Evaluation of O-[3-¹⁸F-fluoropropyl]-α-methyl Tyrosine in Mesothelioma-Bearing Rodents

Table 1

Biodistribution of ¹⁸F-FPAMT in rats.

% of injected dose per gram of tissue weight (𝑛=3/time, interval (iv))
	30 min	90 min	180 min
Blood	0.37±0.07	0.11±0.01	0.04±0.00
Heart	0.32±0.04	0.12±0.01	0.04±0.00
Lungs	0.31±0.06	0.09±0.01	0.03±0.00
Thyroid	0.28±0.01	0.14±0.01	0.09±0.01
Pancreas	0.84±0.11	0.19±0.03	0.07±0.01
Liver	0.49±0.06	0.14±0.01	0.05±0.00
Spleen	0.34±0.05	0.09±0.01	0.03±0.00
Kidneys	3.86±0.74	0.90±0.13	0.40±0.02
Stomach	0.27±0.03	0.09±0.01	0.03±0.00
Intestines	0.37±0.04	0.15±0.05	0.04±0.00
Uterus	0.27±0.03	0.07±0.01	0.03±0.00
Muscle	0.27±0.03	0.15±0.01	0.07±0.01
Bone	0.11±0.01	0.10±0.02	0.19±0.05
Brain	0.02±0.00	0.01±0.00	0.01±0.00

Values shown represent the mean ± standard deviation of data from 3 animals.