Evidence for the Treatment of Osteoporosis with Vitamin D in Residential Care and in the Community Dwelling Elderly
Table 4
Fracture outcomes in community and mixed population studies.
Duration
Regimen
Compliance (%)
Total fracture patients (%)
Non-vertebral fracture patients (%)
Hip fracture patients (%)
RECORD
Median 45 months (range 24–62)
D/CaD
47–60
353 (13)
349 (13)
93 (4)
CaP/P
345 (13)
341 (12)
90 (3)
RRR
NS
NS
NS
Porthouse
Median 25 months (range 18–42)
CaD
63
58 (4)
NA
8 (1)
P
91 (5)
NA
17 (1)
RRR
NS
NA
NS
WHI subgroup
7 years (mean)
CaD
59
NA
NA
115 (3)
P
NA
NA
93 (4)
RRR
NA
NA
NS
Heikinheimo
Range 2–5 years
D
NA
56 (16)
48 (14)
25 (7)
P
100 (22)
94 (21)
43 (9)
RRR
NR ()
NA
NS
Lips
Maximum 3.5 years
D
85
NA
135 (10)
58 (4)
P
NA
122 (9)
48 (4)
RRR
NA
NS
NS
Smith
3 years
D
NA
NA
306 (6)
66 (1)
P
NA
279 (6)
44 (1)
RR Increase
NA
NS
49% ()
ITT analysis unless otherwise stated. D: vitamin D; CaD: calcium and vitamin D combination treatment; P: placebo or control; RRR: relative risk reduction; NA: not available; NS: not significant; RRR: relative risk reduction; NS: not significant; NR: not reported; NA: not available.
