BioMed Research International / 2013 / Article / Fig 1

Review Article

Hepatitis C Virus NS3 Inhibitors: Current and Future Perspectives

Figure 1

HCV genome and polyprotein processing. (a) Open arrow, closed arrows, closed circle, and open circles indicated signal peptide peptidase, signal peptidase, NS2 autoprotease, and NS3-4A serine protease cleavage site(s), respectively. (b) This figure was drawn by UCSF Chimera (, a software program for visualizing molecules, with the structural data from Protein Data Bank (PDB) ID 3O8R. Each domain of NS3 was color-coded. Both blue and purple represent helicase core domain, and green and yellow indicate C-terminal region and protease domain, respectively. ADP and RNA were drawn in red as ligands.

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