Stat3 Inhibits PTPN13 Expression in Squamous Cell Lung Carcinoma through Recruitment of HDAC5
Figure 3
Stat3 knockdown up-regulates PTPN13 expression. ((a)-(b)) HCC-1588 and SK-MES-1 cells were transfected for nonspecific control (Ctrl) or Stat3 siRNA. Endogenous protein levels of Stat3 were determined. ((c)-(d)) mRNA levels of PTPN13 were analyzed by real-time PCR in HCC-1588 (c) and SK-MES-1 (d) cells transfected for nonspecific control (Ctrl) or Stat3 siRNA. ((e)-(f)) Protein levels of PTPN13 were analyzed by western blot in HCC-1588 (e) and SK-MES-1 (f) cells transfected for nonspecific control (Ctrl) or Stat3 siRNA.
