Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats
Table 3
Effects of paracetamol injury and A. blazei pretreatment on oxidative stress indicators in the liver and brain tissues. For experimental details see Section 2.
Parameters
Organ
I, control
II, A. blazei pretreatment
III, paracetamol injury
IV, A. blazei pretreatment + paracetamol injury
TBARS (nmol mg−1)
Liver
1.05 ± 0.19 ()
1.01 ± 0.18 ()
2.08 ± 0.23 ()a,b,c
1.08 ± 0.16 ()
Brain
2.64 ± 0.08 ()
2.73 ± 0.11 ()
3.29 ± 0.21 ()a,b,c
2.61 ± 0.18 ()
ROS (nmol mg−1)
Liver
1.96 ± 0.38 ()
2.31 ± 0.28 ()
2.48 ± 0.48 ()
2.23 ± 0.47 ()
Brain
8.31 ± 0.91 ()
8.63 ± 0.66 ()
9.62 ± 0.69 ()
8.61 ± 0.74 ()
GSH (nmol mg−1)
Liver
13.66 ± 0.65 ()
13.14 ± 0.71 ()
9.76 ± 0.91 ()f,g
12.66 ± 2.02 ()
Brain
8.82 ± 0.19 ()
8.79 ± 0.61 ()
7.31 ± 0.23 ()h
8.28 ± 0.45 ()
Protein thiol groups (nmol mg−1)
Liver
115.3 ± 14.0 ()
122.6 ± 14.7 ()
80.7 ± 7.4 ()
101.1 ± 2.0 (4)
Brain
95.2 ± 5.5 ()
95.0 ± 4.8 ()
84.4 ± 3.6 ()
84.4 ± 3.5 ()
Significant differences (), according to one-way ANOVA followed by Student-Newman-Keuls post-hoc testing, are identified by the superscript letters as follows: aIII versus I; bIII versus II; cIII versus IV. Significant differences according to Student’s -test are given by the codes: f = 0.013 for III versus I; g = 0.026 for III versus I; h < 0.001 for III versus I.
