Effects of an Agaricus blazei Aqueous Extract Pretreatment on Paracetamol-Induced Brain and Liver Injury in Rats
Table 6
Effects of paracetamol injury and A. blazei pretreatment on hepatic glycogen and lipid levels. Livers from fed rats were utilized. For additional experimental details see Section 2.
Parameters
I, control
II, extract treatment
III, paracetamol injury
IV, A. blazei pretreatment + paracetamol injury
Hepatic glycogen (μmol glucosyl units/g liver)
260.4 ± 16.9 ()
273.3 ± 7.4 ()
202.3 ± 4.5 ()a,b
223.8 ± 21.5 ()d
Total lipids (g/100 g liver)
3.66 ± 0.13 ()
3.62 ± 0.16 ()
3.11 ± 0.17 ()
3.58 ± 0.19 ()
Hepatic triglycerides (mg/g total lipids)
96.61 ± 7.51 ()
107.98 ± 10.66 ()
113.75 ± 4.56 ()
85.22 ± 19.75 ()
Cholesterol (mg/g total lipids)
39.49 ± 2.99 ()
45.31 ± 3.85 ()
84.49 ± 5.03 ()a,b,c
47.24 ± 9.09 ()
HDL cholesterol (mg/g total lipids)
1.64 ± 0.12 ()
2.61 ± 0.20 ()e
2.90 ± 0.31 ()a,c
1.91 ± 0.36 ()
Significant differences (), according to one-way ANOVA followed by Student-Newman-Keuls post-hoc testing, are identified by the superscript letters as follows: aIII versus I; bIII versus II; cIII versus IV; dIV versus I; eII versus I.
