Modulation of the Effects of Lung Immune Response on Bone Marrow by Oral Antigen Exposure

Figure 3

Coordinate regulation of eosinophil and neutrophil numbers by oral tolerization. Experimental groups of BP-2 mice were the same as in Figure 1. Data (Mean ± SEM) are (a) numbers of EPO+ cells (black bars) and neutrophils (white bars) in freshly harvested femoral bone marrow of OVA/OVA/OVA and H₂O/OVA/OVA mice (𝑛=3); *𝑃≤0.003 for the indicated differences. (b) Numbers of neutrophils recovered after 6 days from liquid bone marrow cultures established with GM-CSF from the indicated groups 𝑛=4; 𝑃=0.005. (c) Total numbers of colonies formed by bone marrow from the indicated groups in the presence of GM-CSF (𝑛=6); *𝑃≤0.02 for the indicated differences. (d) Counts of colonies containing EPO+ cells from the experiment shown in (c), 𝑛=6; 𝑃≤0.009 for the indicated differences.

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