New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity

Table 1

Mediation analysis.

Genotype dataset	Enzyme	SNP effect	No. of sig. trios; 𝑃<10^−5	No. of sig. SNPs; 𝑃<10^−5	No. of sig. exp; 𝑃<10^−5	FDR; (trios)
Affymetrix	CYP2D6	Gene dose	389,573	103,369	3,545	16.63%
Illumina array	CYP2D6	Gene dose	1,214,416	251,738	4,770	11.73%