New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity

Table 4

Functional annotations of the mediators.

Types	Affymetrix no. Mediator genes	Illumina no. Mediator genes
Cytokine	5	7
Enzyme	246	368
G-protein coupled receptor	17	20
Growth factor	5	11
Ion channel	13	18
Kinase	52	62
Ligand-dependent nuclear receptor	5	7
Other	373	596
Peptidase	31	39
Phosphatase	15	21
Transcription regulator	82	118
Translation regulator	6	10
Transmembrane receptor	12	16
Transporter	77	127
Sum	939	1420