Sabiporide Reduces Ischemia-Induced Arrhythmias and Myocardial Infarction and Attenuates ERK Phosphorylation and iNOS Induction in Rats
Figure 4
ERK1/2 expression and phosphorylation and iNOS expression in heart tissues from rats subjected to coronary ligation and reperfusion. Sabiporide (1.0 mg/kg) was given 10 min prior to coronary occlusion or immediately before reperfusion. (a) Representative blots of phosphorylated ERK1/2 and total ERK1/2 in heart tissues. (b) Statistical data obtained from quantitative densitometry of phos-ERK1/2 in heart tissues. (c) Representative blots of iNOS expression. (d) Statistical data obtained from quantitative densitometry of iNOS in heart tissues. Data are the , . versus sham. versus the vehicle control group.