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BioMed Research International
Volume 2013, Article ID 507216, 8 pages
Clinical Study

Cardiovascular Autonomic Neuropathy in Context of Other Complications of Type 2 Diabetes Mellitus

1Department of Neurology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania
2Mureş County Clinical Emergency Hospital, Târgu Mureş, Gheorghe Marinescu, No. 50, 540136, Romania
3Department of Epidemiology, University of Medicine and Pharmacy Târgu Mureş, Târgu Mureş, Gheorghe Marinescu, No. 38, 540139, Romania

Received 24 April 2013; Revised 20 September 2013; Accepted 4 October 2013

Academic Editor: Eberval G. Figueiredo

Copyright © 2013 Anca Moţăţăianu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study was to investigate the relationship between cardiac autonomic neuropathy (CAN) and other micro- and macrovascular complications and risk factors for type 2 diabetes. We included, in this study, 149 patients with type 2 diabetes. We evaluated their cardiovascular risk factors, demographic data, and any major micro- and macrovascular complications of their diabetes. Assessments of CAN were based upon Ewing’s battery. Results. CAN was present in 38.9% of patients. In the CAN group, the duration of diabetes, BMI, systolic blood pressure, lipid levels, and HBA1c were all significantly higher than those in the other group. A significant association was found between CAN and retinopathy, peripheral neuropathy, ABI, and IMT. Multivariate logistic regression demonstrated that, in type 2 diabetes, the odds of CAN (OR (95% confidence intervals)) increase with the age of the patients (1.68 (1,4129–2.0025)), the average diabetes duration (0.57 (0.47–0.67)), cholesterol (1.009 (1.00-1.01)), HbA1c levels (1.88 (1.31–2.72)), peripheral neuropathy (15.47 (5.16–46.38)), BMI (1.12 (1.05–1.21)), and smoking (2.21 (1.08–4.53)). Conclusions. This study shows that CAN in type 2 diabetes is significantly associated with other macro- and microvascular complications and that there are important modifiable risk factors for its development.